Team describes simple way to generate mouse and bovine cholangiocyte organoids

In a paper published in hLife, a team of Chinese scientists describes simple procedures for generating mouse and bovine cholangiocyte organoids and establishing an in vitro system for culturing Cryptosporidium and transcriptomic studies of biliary cryptosporidiosis. The team established a culture system for the cultivation of Cryptosporidium parvum derived from mouse and bovine cholangiocyte organoids. This team described simple procedures for the generation of mouse and bovine Chol-orgs, and the establishment of an in vitro model of biliary cryptosporidiosis. The results of this study provide a convenient method to study Cryptosporidium-host interactions and biliary cryptosporidiosis. The cholangiocyte organoid culture system will greatly facilitate further studies on the pathogenesis and effective therapies for AIDS cholangiopathy and other liver infections. More information: Miner Deng et al, A cholangiocyte organoid system for Cryptosporidium parvum cultivation and transcriptomic studies of biliary cryptosporidiosis, hLife. Citation: Team describes simple way to generate mouse and bovine cholangiocyte organoids retrieved 9 July 2024 from https://phys. org/news/2024-07-team-simple-generate-mouse-bovine.